Kardos, a preparation containing ultralow doses of antibodies to C-terminal fragment of type 1 receptor of angiotensin II, intragastrically administered to SHR rats with hereditary hypertension for 28 days reduced blood pressure by 14.8%. Kardos was not inferior to losartan and, in contrast to the latter reduced HR by 9.4%.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
B. Baudin, Exp. Physiol., 90, No. 3, 277-282 (2005).
H. Gavras and H. R. Brunner, Hypertension, 37, No. 2, Pt. 2, 342-345 (2001).
S. Miura, K. Saku, and S. S. Karnik, Hypertens. Res., 26, No. 12, 937-943 (2003).
A. B. Ribeiro, Curr. Med. Res. Opin., 22, No. 1, 1-16 (2006).
R. A. Santos, A. J. Ferreira, S. V. Pinheiro, et al., Expert Opin. Investig. Drugs., 14, No. 8, 1019-1031 (2005).
C. Szabo ,P. Pacher, Z. Zsengeller, et al., Mol. Med., 10, No. 1-6, 28-35 (2004).
K. von Bohlen and O. Halbach, Curr. Protein Pept. Sci., 6, No. 4, 355-371 (2005).
C. Zhang, T. W. Hein, W. Wang, and L. Kuo, Circ. Res., 92, No. 3, 322-329 (2003).
Author information
Authors and Affiliations
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, Suppl. 1, pp. 160-163, September, 2009
Rights and permissions
About this article
Cite this article
Medvedeva, N.A., Artem’eva, M.M., Kheyfets, I.A. et al. Experimental Study of Hypotensive Effect of Kardos in Rats with Inherited Hypertension. Bull Exp Biol Med 148, 520–523 (2009). https://doi.org/10.1007/s10517-010-0753-2
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-010-0753-2