Skip to main content

Advertisement

SpringerLink
Log in

A Method for Evaluation of Therapeutic Dose of Doxorubicin Hydrochloride Using Breast Tumor Cell Culture MCF-7

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Growth kinetics of human breast tumor cell in the presence of doxorubicin was studied using the method of UV spectrophotometery. Parameters of ecotoxicological cell growth model were established. Cell number predicted by the model equation corresponded to the observed cell count within the experimental error. The therapeutic dose of doxorubicin hydrochloride was determined.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. G. N. Apryshko, V. V. Reshetnikova, D. V. Filimonov, et al., Ros. Bioterapevt. Zh., 4, No. 1, 46 (2005).

    Google Scholar 

  2. D. Yu. Blokhin, Ibid., 4, No. 1, 47 (2005).

    Google Scholar 

  3. Yu. A. Ershov, Dokl. Akad. Nauk, 352, No. 5, 627-629 (1996).

    Google Scholar 

  4. Yu. A. Ershov, Zh. Fiz. Khim., 72, No. 3, 553-559 (1998).

    CAS  Google Scholar 

  5. Yu. A. Ershov, L. N. Kublik, T. V. Pletneva, and L. Kh. Eidus, Bull. Eksper. Biol., 113, No. 3, 283-284 (1992).

    Google Scholar 

  6. Yu. A. Ershov, T. V. Pletneva, and N. B. Esmenskaya, Khim. Farm. Zh., 29, No. 11, 6-8 (1995).

    CAS  Google Scholar 

  7. Yu. A. Ershov, T. V. Pletneva, T. K. Slonskaya, Ibid., 123, No. 5, 594-600 (1997).

    Google Scholar 

  8. E. V. Ignat’eva, A. P. Polozkova, O. L. Orlova, Ros. Bioterapevt. Zh., 4, No. 1, 47 (2005).

    Google Scholar 

  9. Russian Cell Culture Collection Catalog [In Russian], St. Petersburg—Omsk (1999).

  10. O. N. Konyaeva, L. M. Mikhailova, I. B. Merkulova, et al., Ros. Bioterapevt. Zh., 5, 15-16 (2006)

    Google Scholar 

  11. A. N. Tevyashova, E. N. Olsuf’eva, A. A. Shtil’, et al., Ibid., 4, No. 1, 72 (2005).

    Google Scholar 

  12. V. I. Chissov, N. S. Sergeeva, I. K. Sviridova, et al., Ibid., 5, No. 2, 7-9 (2006).

    Google Scholar 

  13. Yu. A. Ershov and V. V. Kotin, Chemical and Biochemical Physics: New Frontiers / Ed. G. E. Zaikov, N. Y., P. 87-111 (2006).

  14. A. N. Gordon, J. T. Fleagle, D. Guthrie, et al., J. Clin. Oncol., 19, No. 14, 3312-3322 (2001)

    CAS  PubMed  Google Scholar 

  15. A. N. Gordon, C. O. Granai, P. G. Rose, et al., Ibid, 18, No. 17, 3093-3100 (2000).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. P. A. Hertzen Research Institute of Oncology, Federal Agency for High Technology Medical Aid, Moscow, Russia

    Ya. D. Shanskij

  2. I. M. Sechenov Moscow Medical Academy, Federal Agency of Health Care and Social Development, Moscow, Russia

    Yu. A. Ershov & V. M. Pechennikov

Authors
  1. Ya. D. Shanskij
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yu. A. Ershov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. M. Pechennikov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ya. D. Shanskij.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 9, pp. 356-359, September, 2009

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shanskij, Y.D., Ershov, Y.A. & Pechennikov, V.M. A Method for Evaluation of Therapeutic Dose of Doxorubicin Hydrochloride Using Breast Tumor Cell Culture MCF-7. Bull Exp Biol Med 148, 464–467 (2009). https://doi.org/10.1007/s10517-010-0737-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-010-0737-2

Key Words

Search

Navigation