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The Law of Stage-by-Stage Development of Human Tumors, Derived from the Results of Ploidometric Studies

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Bulletin of Experimental Biology and Medicine Aims and scope

The ploidy of 56,000 epithelial cell nuclei was studied at different stages of carcinogenesis by Imager-CG computer image analyzer. The linear relationship between carcinogenesis stages and quantitative parameters (indexes of mean ploidy of cell nuclei) at a certain stage was detected and mathematically described. A step-by-step increase of DNA content in cell nuclei by one unit of ploidy leads to emergence of new biological properties, measured by the number of units surpassing the normal cell nuclear ploidy values, which was called “the malignancy code”.

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Authors and Affiliations

  1. Russian Medical Upgrading Academy, Moscow, Russia

    G. G. Avtandilov

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  1. G. G. Avtandilov
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Correspondence to G. G. Avtandilov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 9, pp. 318-321, September, 2009

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Avtandilov, G.G. The Law of Stage-by-Stage Development of Human Tumors, Derived from the Results of Ploidometric Studies. Bull Exp Biol Med 148, 429–432 (2009). https://doi.org/10.1007/s10517-010-0729-2

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  • DOI: https://doi.org/10.1007/s10517-010-0729-2

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