Experiments on outbred albino rats showed that administration of acetylcholine and aceclidine in a dose of 0.1 LD50 for 3 days and of dimethyl dichlorovinyl phosphate (organophosphorus compound) in a single dose of 0.05 LD50 stimulated the function of Th1 and Th2 lymphocytes and cytokine production by these cells. Dimethyl dichlorovinyl phosphate in a single dose of 0.5 LD50 produced an opposite effect. Acetylcholine and aceclidine stimulated activity of acetylcholinesterase in T cells, while dimethyl dichlorovinyl phosphate in a single dose of 0.5 LD50 inhibited it. During acute intoxication, the organophosphorus compound, depending on the dose, can stimulate (acetylcholine effect) and inhibit the immune reactions (acetylcholinesterase inhibition of T cells).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 9, pp. 287-290, September, 2009
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Zabrodskii, P.F., Kirichuk, V.F., Lim, V.G. et al. Role of Cholinergic and Cytokine Regulation of T Cell Function in Stimulation and Inhibition of Immune Reactions in Intoxication by Organophosphorus Compounds in Different Doses. Bull Exp Biol Med 148, 399–402 (2009). https://doi.org/10.1007/s10517-010-0722-9
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DOI: https://doi.org/10.1007/s10517-010-0722-9