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Proliferation and Survival of Rat C6 Glioma Culture in the Presence of Implants Coated with Modified Carbon-Based Films

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Bulletin of Experimental Biology and Medicine Aims and scope

The survival of rat C6 glioma decreased in the presence of implants from VT-16 titanium alloy. Diamond-like carbon coating of VT-16 alloy slightly increased cell death on day 5 of the experiment (39.9±2.1%). The percentage of dead C6 glioma cells inside titanium rings with diamond-like carbon coating, incorporating up to 3.5 atom.% Ag nanoparticles, was 53.7±4.3% on day 5 of culturing, while after doping to 6.7 atom.% Ag cell death reached 66.7±3.2% (p<0.05). The maximum toxic effect towards C6 glioma was detected in the specimens coated with diamond-like film with silver nanoparticles.

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Authors and Affiliations

  1. Department of Physiology and General Pathology, Institute of Physio logy, National Academy of Sciences of Belarus, Minsk, Belarus

    L. V. Pozdniak, A. N. Chernov, V. V. Akulich & V. A. Kulchitsky

  2. Physical Technological Institute, National Academy of Sciences of Belarus, Minsk, Belarus

    N. M. Chekan, N. M. Beliauski & A. I. Gordienko

  3. Cell Culture Bank Group, Department of Cell Cultures, Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia

    G. G. Poljanskaya

Authors
  1. L. V. Pozdniak
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  2. A. N. Chernov
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  3. N. M. Chekan
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  4. N. M. Beliauski
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  5. V. V. Akulich
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  6. G. G. Poljanskaya
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  7. A. I. Gordienko
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  8. V. A. Kulchitsky
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Corresponding author

Correspondence to V. A. Kulchitsky.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 8, pp. 226–230, August, 2009

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Pozdniak, L.V., Chernov, A.N., Chekan, N.M. et al. Proliferation and Survival of Rat C6 Glioma Culture in the Presence of Implants Coated with Modified Carbon-Based Films. Bull Exp Biol Med 148, 253 (2009). https://doi.org/10.1007/s10517-009-0709-6

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  • DOI: https://doi.org/10.1007/s10517-009-0709-6

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