We studied isolated pontobulbospinal preparations from newborn rat brain. In the early postnatal period, the rostral part of the medial vestibular nucleus produces a potent inhibitory effect on neuronal structures of the bulbar respiratory center via the glutamatergic system. Microinjection of L-glutamate (50 mmol/liter) into the rostral part of the vestibular nucleus completely blocks respiratory rhythmogenesis in 0-1-day-old rat pups and reduced the frequency of generation of inspiratory discharges in 2-3-day-old rats from 8.42±0.68 to 2.68±0.32 min—1. It was found that the leading role in the mechanism of glutamatergic modulation of the respiratory rhythmogenesis by neurons of the medial vestibular nucleus is played by NMDA and, to a lesser extent, non-NMDA glutamate receptors.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 8, pp. 129-132, August, 2009
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Tyurin, N.L. Role of Neuronal NMDA and non-NMDA Glutamate Receptors in Medial Vestibular Nucleus in the Regulation of Respiratory Rhythmogenesis in Newborn Rats In Vitro . Bull Exp Biol Med 148, 167–170 (2009). https://doi.org/10.1007/s10517-009-0676-y
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DOI: https://doi.org/10.1007/s10517-009-0676-y