We studied the effect of acute emotional stress and exogenous IL-1β (5 μg/kg intraperitoneally) on the cytokine profile of blood serum in Wistar rats with various behavioral characteristics in the open-field test. Blood level of proinfl ammatory cytokine IL-1β decreased in behaviorally passive rats, but increased in active animals after simultaneous immobilization and electrocutaneous stimulation. These changes refl ect the opposite immune responses to a similar stress exposure in rats with different emotional reactivity. Poststress variations in the concentration of circulating IL-1β differed in rats receiving exogenous IL-1β. Blood cytokine concentration decreased in behaviorally active rats, but remained unchanged in passive animals that were exposed to immobilization and electrocutaneous stimulation after pretreatment with IL-1β. Emotional stress and injection of IL-1β had no effect on blood level of an anti-infl ammatory cytokine IL-4 in rats. Our results indicate that rats with various behavioral parameters are characterized by significant differences in the cytokine profile of blood serum under conditions of emotional stress and treatment with IL-1β. These data illustrate the specific functional features of immune mechanisms, which provide an individual resistance of rats to the same stress exposure.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 8, pp. 161–165, August, 2009
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Pertsov, S.S., Koplik, E.V., Stepanyuk, V.L. et al. Blood Cytokines in Rats with Various Behavioral Characteristics during Emotional Stress and Treatment with Interleukin-1β. Bull Exp Biol Med 148, 196–199 (2009). https://doi.org/10.1007/s10517-009-0668-y
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DOI: https://doi.org/10.1007/s10517-009-0668-y