Peptide Regulation of Aging: 35-Year Research Experience

Biogerontology

The authors sum up the results of many-year studies of mechanisms of aging and efficiency of peptide bioregulators in the prevention of age-specific diseases. Data on the effects of peptides, evaluated by the up-to-date methods, are presented. A molecular model of complementary interactions between short peptides and gene promotor sites, underlying the initiation of protein synthesis, is proposed. Prospects of peptide bioregulators in prevention of early aging are discussed.

Key Words

peptide bioregulators aging age-specific disease cancer prevention 

References

  1. 1.
    V. N. Anisimov, I. G. Popovich, M. A. Zabezhinskii, et al., Vopr. Onkol., 51, No. 1, 93–98 (2005).PubMedGoogle Scholar
  2. 2.
    V. N. Anisimov and V. Kh. Khavinson, Dokl. Akad. Nauk SSSR, 319, 250–254 (1991).PubMedGoogle Scholar
  3. 3.
    V. N. Anisimov, V. Kh. Khavinson, V. G. Morozov, and V. M. Dilman, Ibid., 213, 483–485 (1973).Google Scholar
  4. 4.
    S. V. Anisimov, K. R. Bogiler, V. Kh. Khavinson, and V. N. Anisimov, Byull. Eksp. Biol. Med., 133, No. 3, 340–347 (2002).CrossRefGoogle Scholar
  5. 5.
    I. A. Vinogradova, A. V. Bukalev, M. A. Zabezhinskii, et al., Ibid., 144, No. 12, 676–681 (2007).Google Scholar
  6. 6.
    I. A. Vinogradova, A. V. Bukalev, M. A. Zabezhinskii, et al., Ibid., 145, No. 4, 455–460 (2008).Google Scholar
  7. 7.
    O. V. Korkushko, V. Kh. Khavinson, V. B. Shatilo, and I. A. Antonyuk-Shcheglova, Ibid., 142, No. 9, 328–332 (2006).Google Scholar
  8. 8.
    O. V. Korkushko, V. Kh. Khavinson, V. B. Shatilo, and L. V. Magdich, Ibid., 137, No. 4, 441–443 (2004).Google Scholar
  9. 9.
    I. Yu. Ryadnova, L. K. Shataeva, and V. Kh. Khavinson, Vysokomolek. Soed., 42, 833–839 (2000).Google Scholar
  10. 10.
    V. Kh. Khavinson and V. N. Anisimov, Peptide Bioregulators and Aging [in Russian], St. Petersburg (2003).Google Scholar
  11. 11.
    V. Kh. Khavinson, S. V. Anisimov, V. V. Malinin, and V. N. Anisimov, Peptide Regulation of the Genome and Aging [in Russian], Moscow (2005).Google Scholar
  12. 12.
    V. Kh. Khavinson, I. E. Bondarev, A. A. Butyugov, and T. D. Smirnova, Byull. Eksp. Biol. Med., 137, No. 5, 573–577 (2004).CrossRefGoogle Scholar
  13. 13.
    V. Kh. Khavinson, A. Yu. Solovyov, and L. K. Shataeva, Ibid., 146, No. 11, 560–562 (2008).Google Scholar
  14. 14.
    S. V. Anisimov, V. Kh. Khavinson, and V. N. Anisimov, Neuro Endocrinol. Lett., 25, Nos. 1–2, 87–93 (2004).PubMedGoogle Scholar
  15. 15.
    V. N. Anisimov, A. V. Arutjunyan, and V. Kh. Khavinson, Ibid., 22, No. 1, 9–18 (2001).Google Scholar
  16. 16.
    V. N. Anisimov, V. Kh. Khavinson, A. I. Mikhalski, and A. I. Yashin, Mech. Ageing Dev., 122, No. 1, 41–68 (2001).CrossRefPubMedGoogle Scholar
  17. 17.
    V. N. Anisimov, V. Kh. Khavinson, and V. G. Morozov, Biogerontology, 1, No. 1, 55–59 (2000).CrossRefPubMedGoogle Scholar
  18. 18.
    V. N. Anisimov, V. Kh. Khavinson, and V. G. Morozov, Mech. Ageing Dev., 19, No. 3, 245–258 (1982).CrossRefPubMedGoogle Scholar
  19. 19.
    V. N. Anisimov, V. Kh. Khavinson, I. G. Popovich, et al., Biogerontology, 4, No. 4, 193–202 (2003).CrossRefPubMedGoogle Scholar
  20. 20.
    V. N. Anisimov, V. Kh. Khavinson, M. Provinciali, et al., Int. J. Cancer, 101, No. 1, 7–10 (2002).CrossRefPubMedGoogle Scholar
  21. 21.
    V. N. Anisimov, A. S. Loktionov, V. Kh. Khavinson, and V. G. Morozov, Mech. Ageing Dev., 49, No. 3, 245–257 (1989).CrossRefPubMedGoogle Scholar
  22. 22.
    V. N. Anisimov, S. V. Mylnikov, T. I. Oparina, and V. Kh. Khavinson, Ibid., 97, No. 2, 81–91 (1997).Google Scholar
  23. 23.
    V. M. Dilman, V. N. Anisimov, M. N. Ostroumova, et al., Exp. Pathol., 17, No. 9, 539–545 (1979).Google Scholar
  24. 24.
    N. D. Goncharova, A. A. Vengerin, V. Kh. Khavinson, and B. A. Lapin, Exp. Gerontol., 40, Nos. 1–2, 51–57 (2005).CrossRefPubMedGoogle Scholar
  25. 25.
    V. Kh. Khavinson and V. V. Malinin, Gerontological Aspects of Genome Peptide Regulation, Basle — Switzerland (2005).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  1. 1.St. Petersburg Institute of Bioregulation and GerontologyNorth-Western Division of the Russian Academy of Medical SciencesSt. PetersburgRussia
  2. 2.N. N. Petrov Institute of OncologyMinistry of Health and Social Development of the Russian FederationSt. PetersburgRussia

Personalised recommendations