Skip to main content

Advertisement

Log in

Mononuclear Leukocytes from Mice with Resected Tumor Induce Resistance to Transplantation of Tumor Cells to Animals

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Experiments on male C57Bl/6 mice with intraperitoneally transplanted Ehrlich carcinoma and DBA/2 mice with subcutaneously transplanted S-91 melanoma showed that preliminary injection of mononuclear leukocytes obtained from animals 6–8 h after tumor resection induce resistance to transplantation of malignant transformed cells. Our results suggest that not only humoral factors, but also immunocompetent cells are involved in the regulation of tumor growth. The resistance to tumor transplantation was not induced by mononuclear leukocytes isolated over the first hours and 10–12 h after removal of the primary tumor node, which excludes the direct cytotoxic effect of these cells and suggests that this phenomenon is not associated with activation of the effector mechanisms for innate and adoptive immunity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S. M. Sitdikova, B. S. Amandzholov, M. V. Kiselevskii, and F. V. Donenko, Byull. Eksp. Biol. Med., 143, No. 1, 86–88 (2007).

    Article  Google Scholar 

  2. S. M. Sitdikova, B. S. Amandzholov, V. Yu. Sel’chuk, and F. V. Donenko, Ibid., 135, No. 6, 676–679 (2003).

    Google Scholar 

  3. F. V. Donenko, S. M. Sitdikova, A. V. Syrtsev, et al., Intern. J. Oncology, 32, No. 4, 885–893 (2008).

    CAS  Google Scholar 

  4. B. Fisher, N. Gunduz, J. Coyle, et al., Cancer Res., 49, No. 8, 1996–2001 (1989).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. M. Sitdikova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 7, pp. 100–102, July, 2009

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sitdikova, S.M., Kiselevskii, M.V., Sel’chuk, V.Y. et al. Mononuclear Leukocytes from Mice with Resected Tumor Induce Resistance to Transplantation of Tumor Cells to Animals. Bull Exp Biol Med 148, 86–88 (2009). https://doi.org/10.1007/s10517-009-0648-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-009-0648-2

Key Words

Navigation