We studied the effect of adrenal cortex hormone dehydroepiandrosterone sulfate on maturation and functional activity of interferon-α-induced dendritic cells. Dehydroepiandrosterone sulfate stimulated differentiation and maturation of interferon-α-induced dendritic cell, which manifested in a decrease in the number of CD14+ cells and increase in the ratio of mature CD83+ dendritic cells expressing costimulatory molecules (CD80 and CD86). The induction of dendritic cell differentiation after treatment with dehydroepiandrosterone sulfate was accompanied by an increase in the production of interferon-γ. At the stage of dendritic cell maturation, the effect of dehydroepiandrosterone sulfate manifested in a 4-fold increase in tumor necrosis factor-α production. Dehydroepiandrosterone sulfate had little effect on the production of Th2/antiinfl ammatory cytokines at the stages of differentiation and maturation of interferon-α-induced dendritic cells. Dehydroepiandrosterone sulfate increased the ability of dendritic cells to stimulate Th1 cytokine production by T cells (interferon-γ). This hormone had no effect on the ability of interferon-α-induced dendritic cells to activate CD3+IL-4+T cells in mixed lymphocyte culture.
Similar content being viewed by others
References
J. Banchereau and R. M. Steinman, Nature, 392, 245-252 (1998).
M. O. Canning, K. Grotenhuis, H. J. de Wit, and H. A. Drexhage, Eur. J. Endocrin., 143, No. 5, 687-695 (2000).
S. Della Bella, S. Nicola, A. Riva, et al., J. Leuk. Biol., 75, No. 1, 106-116 (2004).
C. Dosiou and L. C. Giudice, Endocr. Rev., 26, No. 1, 44-62 (2005).
H. Ida, P. J. Utz, P. Anderson, and K. Eguchi, Mod. Rheumatol., 15, No. 5, 315-322 (2005).
H. Jonuleit, U. Kuhn, C. Muller, et al., Eur. J. Immunol., 27, No. 12, 3135-3142 (1997).
T. Okabe, M. Haji, R. Takayanagi, et al., J. Clin. Endocrinol. Metab., 80, No. 10, 2993-2996 (1995).
S. Parlato, S. M. Santini, C. Lapenta, et al., Blood, 98, No. 10, 3022-3029 (2001).
W. F. Pickl, O. Majdic, P. Kohl, et al., J. Immunol., 157, No. 9, 3850-3859 (1996).
R. Raghupathy, Semin. Immunol., 13, No. 4, 219-227 (2001).
S. M. Santini, C. Lapenta, M. Logozzi, et al., J. Exp. Med., 191, No. 10, 1777-1788 (2000).
S. M. Santini, T. Di Pucchio, C. Lapenta, et al., Stem Cells, 21, No. 3, 357-362 (2003).
B. Solerte, S. Precerutti, C. Gazzaruso, et al., Eur. J. Endocrin., 152, No. 5, 703-712 (2005).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’oi Biologii i Meditsiny, Vol. 148, No. 7, pp. 80-84, July, 2009
Rights and permissions
About this article
Cite this article
Leplina, O.Y., Tikhonova, M.A., Sakchno, L.V. et al. Effect of Dehydroepiandrosterone Sulfate on Maturation and Functional Properties of Interferon-α-Induced Dendritic Cells. Bull Exp Biol Med 148, 68–71 (2009). https://doi.org/10.1007/s10517-009-0619-7
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-009-0619-7