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Model for Alternative Splicing of Insulin Receptor in Myotonic Dystrophy Type 1

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Bulletin of Experimental Biology and Medicine Aims and scope

Muscular dystrophy is a common multisystem disease, which results from the impairment of alternative splicing. An increase in the number of unstable CTG and CCTG repeats in untranslated regions of the DMPK and ZNF9 genes is followed by dysregulation of RNA-binding proteins. Further changes are followed by dysfunction of insulin receptors, membrane Cl- channels, and other proteins. We developed a new mathematical model for the regulation of splicing of exon 11 in the IR gene, which describes the effect of various factors on alternative splicing.

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References

  1. J. D. Brook, M. E. McCurrach, H. G. Harley, et al., Cell, 68, No. 4, 799–808 (1992).

    Article  CAS  PubMed  Google Scholar 

  2. L. Cartegni, S. L. Chew, and A. R. Kreiner, Nat. Rev. Genet., 3, No. 4, 285–298 (2002).

    Article  CAS  PubMed  Google Scholar 

  3. W. Dansithong, C. M. Wolf, P. Sarkar, et al., PLoS ONE, 3, No. 12 (2008). [www.plosone.org].

  4. M. Fardaei, M. T. Rogers, H. M. Thorpe, et al., Hum. Mol. Genet., 11, No. 7, 805–814 (2002).

    Article  CAS  PubMed  Google Scholar 

  5. T. H. Ho, N. Charlet-B, M. G. Poulos, et al., EMBO J., 23, No. 15, 3103–3112 (2004).

    Article  CAS  PubMed  Google Scholar 

  6. R. N. Kanadia, J. Shin, Y. Yuan, et al., Nat. Acad. Sci., 103, No. 31, 11,748-11,753 (2006).

    Article  CAS  Google Scholar 

  7. N. M. Kuyumcu-Martinez, G. Wang, and T. A. Cooper, Mol. Cell, 28, No. 1, 68–78 (2007).

    Article  CAS  PubMed  Google Scholar 

  8. X. Lin, J. W. Miller, A. Mankodi, et al., Hum. Mol. Genet., 15, No. 13, 2087–2097 (2006).

    Article  CAS  PubMed  Google Scholar 

  9. C. L. Liquori, Y. Ikeda, M. Weatherspoon, et al., Am. J. Hum. Genet., 73, No. 4, 849–862 (2003).

    Article  CAS  PubMed  Google Scholar 

  10. L. Martorell, D. G. Monckton, J. Gamez, et al., Hum. Mol. Genet., 7, No. 2, 307–312 (1998).

    Article  CAS  PubMed  Google Scholar 

  11. S. Paul, W. Dansithong, D. Kim, et al., EMBO J., 25, No. 18, 4271–4283 (2006).

    Article  CAS  PubMed  Google Scholar 

  12. A. V. Philips, L. T. Timchenko, and T. A. Cooper, Sci., 280, 737–741 (1998).

    Article  CAS  Google Scholar 

  13. S. Reddy, D. B. Smith, M. M. Rich, et al., Nat. Genet., 13, No. 3, 325–335 (1996).

    Article  CAS  PubMed  Google Scholar 

  14. R. S. Savkur, A. V. Philips, and T. A. Cooper, Nat. Genet., 29, No. 1, 40–47 (2001).

    Article  CAS  PubMed  Google Scholar 

  15. M. B. Warf and J. A. Berglund, RNA, 13, No. 12, 2238–2251 (2007).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Russian Research Institute of Sport and Physical Education, Moscow, Russia

    E. A. Tonevitsky & E. V. Trushkin

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  1. E. A. Tonevitsky
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  2. E. V. Trushkin
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Correspondence to E. V. Trushkin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 6, pp. 716–720, June, 2009

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Tonevitsky, E.A., Trushkin, E.V. Model for Alternative Splicing of Insulin Receptor in Myotonic Dystrophy Type 1. Bull Exp Biol Med 147, 772–776 (2009). https://doi.org/10.1007/s10517-009-0611-2

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  • DOI: https://doi.org/10.1007/s10517-009-0611-2

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