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The Rat Spermatogenesis after Injection of Paclitaxel (Antitumor Agent)

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Bulletin of Experimental Biology and Medicine Aims and scope

Morphological and functional characteristics of spermatogenesis in rats were studied during the early and delayed periods after single injection of paclitaxel (antitumor agent) in the maximum tolerated dose. The drug induced structural changes in the gonads associated with oligospermia and increased number of pathological forms of spermatozoa with reduced functional activity.

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    T. G. Borovskaya, V. E. Goldberg, O. A. Rumpel, A. V. Pahomova, A. V. Perova & E. D. Goldberg

  2. Institute of Oncology, Tomsk Research Cente, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    T. G. Borovskaya, V. E. Goldberg, O. A. Rumpel, A. V. Pahomova, A. V. Perova & E. D. Goldberg

Authors
  1. T. G. Borovskaya
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  2. V. E. Goldberg
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  3. O. A. Rumpel
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  4. A. V. Pahomova
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  5. A. V. Perova
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  6. E. D. Goldberg
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Corresponding author

Correspondence to T. G. Borovskaya.

Additional information

Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 147, No. 6, pp. 655-658, June, 2009

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Borovskaya, T.G., Goldberg, V.E., Rumpel, O.A. et al. The Rat Spermatogenesis after Injection of Paclitaxel (Antitumor Agent). Bull Exp Biol Med 147, 715–718 (2009). https://doi.org/10.1007/s10517-009-0596-x

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  • DOI: https://doi.org/10.1007/s10517-009-0596-x

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