Imipramine test (7.5 mg/kg) revealed a persistent positive reaction of Wistar rats, which manifested in reduced excitability of animals. Oral administration of imipramine solution was followed by unstable behavioral reactions in GC rats. Norepinephrine concentration in the cortical and limbic regions of these animals remained unchanged, while plasma corticosterone concentration decreased to the control level and did not differ from that in Wistar rats. Our results indicate that imipramine has a modulatory effect on destabilization of the adaptive system in catatonic GC rats.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 6, pp. 663-666, June, 2009
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Alekhina, T.A., Ukolova, T.N., Kuznetsova, N.V. et al. Effect of Imipramine on Nerve Excitability in GC Rats. Bull Exp Biol Med 147, 722–725 (2009). https://doi.org/10.1007/s10517-009-0594-z
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DOI: https://doi.org/10.1007/s10517-009-0594-z