Our method for evaluating the time course and intensity of antibiotics and other drugs transport in the predominant direction between the blood and lymph in humans promotes a more objective evaluation of drug circulation mechanisms, which is essential for determining the time of their repeated administration and route of administration. Calculation of the lymph/blood difference coefficient, based on parallel repeated measurements of the drug concentration in the lymph and blood, and of the lymph/blood coefficient provides complete data on the direction and time course of drug transport between the lymph and blood in the predominant direction.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 3, pp. 331–334, March, 2009
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Petrovich, Y.A., Yarema, I.V., Kichenko, S.M. et al. Study of Drug Transport between the Blood and Lymph in the Predominant Direction. Bull Exp Biol Med 147, 357–360 (2009). https://doi.org/10.1007/s10517-009-0508-0
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DOI: https://doi.org/10.1007/s10517-009-0508-0