The reproducibility of brain injury was evaluated by simulating ischemia in rats by 30-min occlusion of the middle cerebral artery. The selected ischemia-reperfusion protocol was characterized by high reproduction of the striatal neuron injury, which fact suggests this model for studies of nerve tissue reactions to injury and for evaluation of the efficiency of neuroprotective drugs.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 2, pp. 217-219, February, 2009
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Korzhevskii, D.E., Kirik, O.V., Baisa, A.E. et al. Simulation of Unilateral Ischemic Injury to the Striatal Neurons Inflicted by Short-Term Occlusion of the Middle Cerebral Artery. Bull Exp Biol Med 147, 255–256 (2009). https://doi.org/10.1007/s10517-009-0487-1
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DOI: https://doi.org/10.1007/s10517-009-0487-1