Dynamic studies on rats with chronic endogenous intoxication showed involvement of the thyroid hormones in modulation of liver injury. Thyroid modulation is realized as more intense induction of TNF apoptosis in the cells and stimulation of microcirculatory disorders at the expense of nitroxide synthase expression. The modulation is quantitative, augmenting liver damage.
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References
I. G. Akmaev and V. V. Grinevich, Neuroimmunoendocrinology [in Russian], Moscow (2003).
N. N. Belushkina and S. E. Severin, Arkh. Patol., 63, No. 1, 51-60 (2001).
O. D. Mishnev, A. I. Shchyogolev, N. L. Lysova, and I. O. Tin’kova, The Liver and Kidneys in Endotoxemia [in Russian], Moscow (2003).
V. V. Novochadov and V. B. Pisarev, Endotoxicosis: Simulation and Organ Abnormalities [in Russian], Volgograd (2005).
L. F. Zutphen, V. Baumans, and A. C. Beynen, Principles of Laboratory Animal Science, Amsterdam (1993).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 2, pp. 201-206, February, 2009
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Kalashnikova, S.A., Goryachev, A.N., Novochadov, V.V. et al. Thyroid Modulation of TNF-Dependent Apoptosis and Formation of Chronic Liver Disease in Endogenous Intoxication in Rats. Bull Exp Biol Med 147, 240–244 (2009). https://doi.org/10.1007/s10517-009-0484-4
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DOI: https://doi.org/10.1007/s10517-009-0484-4