We studied effects of chronic thyroxin administration (2 mg/l, for 60 days) on motor activity, anxiety and depression-like behavior in cataleptic (ASC/Icg) and non-cataleptic (AKR/J) strains of mice. No effects of thyroxin on anxiety indicators in “open field” and “light/dark” tests were revealed in mice of the strains under study. At the same time, thyroxin increased moveability in the “open field” test in AKR/J mice and produced an antidepressant effect in the “forced swimming” test in animals from ASC/Icg strain. Obtained results are indicative of the role of inherited predisposition to catalepsy in determining the sensitivity to thyroid hormones.
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Translated from Byulleten’ Experimental’noi Biologii I Meditsiny, Vol. 147, No. 2, pp. 177-180, February, 2009
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Zubkov, E.A., Kulikov, A.V. Effect of Thyroxin on Behavior of Mice with Inherited Difference in Predisposition to Catalepsy. Bull Exp Biol Med 147, 217–219 (2009). https://doi.org/10.1007/s10517-009-0478-2
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DOI: https://doi.org/10.1007/s10517-009-0478-2