Antithrombogenic and antiplatelet effects of a new drug, containing isoflavonoids (extract from the wood of Maackia amyrensis, a Far Eastern plant), were studied. A course (200 mg/kg intragastrically during 14 days) of Maackia amyrensis extract prevented intravascular clotting, initiated by application of 10% iron chloride solution on the vessel. The drug increased antiaggregant activity of the vascular wall and potentiated endothelium-dependent vasodilatation in ovariectomied rats. The reference drug ethinylestradiol (25 μg/kg intragastrically during 14 days) potentiated the antiaggregant effect of the endothelium, but was inferior to Maackia amyrensis extract in the capacity to induce endothelium-dependent vasodilatation in ovariectomied rats.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 2, pp. 164-167, February, 2009
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Plotnikova, A.M., Shulgau, Z.T., Plotnikova, T.M. et al. Antithrombogenic and Antiplatelet Activities of Extract from Maackia amyrensis Wood. Bull Exp Biol Med 147, 204–207 (2009). https://doi.org/10.1007/s10517-009-0475-5
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DOI: https://doi.org/10.1007/s10517-009-0475-5