The renal renin system was studied in ISIAH rats with inherited stress-induced arterial hypertension. The expression of genes for renin (Ren1) and cyclooxygenase (Cox-2) was evaluated in renal tissue of ISIAH and WAG rats (normotensive control). Basal gene expression for Ren1 and Cox-2 in ISIAH rats was much lower than in WAG rats. Water deprivation for 11 h was followed by a 4-fold increase in Cox-2 gene expression in ISIAH rats. The increase in gene expression was insignificant in WAG rats (by 30%). Renin gene expression in renal tissue of ISIAH and WAG rats remained practically unchanged after water deprivation. We conclude that a change in Cox-2 gene expression after short-term water deprivation serves as a reliable criterion for functional strain of the renal renin system in hypertensive ISIAH rats.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 2, pp. 134–138, February, 2009
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Fedoseeva, L.A., Dymshits, G.M., Markel, A.L. et al. Renin System of the Kidney in ISIAH Rats with Inherited Stress-Induced Arterial Hypertension. Bull Exp Biol Med 147, 177–180 (2009). https://doi.org/10.1007/s10517-009-0465-7
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DOI: https://doi.org/10.1007/s10517-009-0465-7