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Antihypoxants, Thiasolo[5,4-b]Indole Derivatives, Increase Exercise Performance in Rats and Mice

The actoptrotective activity of 12 new antihypoxants of the thiasolo[5,4-b]indole series was studied on the model of treadmill running until exhaustion 1 and 24 h after intraperitoneal injection. Highly active compounds more effective than the reference drugs bemithyl and phenamine were found. They increased exercise performance 1 or 24 h after injection or maintained high performance throughout 24 h.

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Correspondence to P. D. Shabanov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 1, pp. 58-61, January, 2009

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Marysheva, V.V., Shabanov, P.D. Antihypoxants, Thiasolo[5,4-b]Indole Derivatives, Increase Exercise Performance in Rats and Mice. Bull Exp Biol Med 147, 55–58 (2009).

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Key Words

  • antihypoxants
  • physical performance
  • thiasolo[5,4-b]indole
  • phenamine
  • bemithyl