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Antihypoxants, Thiasolo[5,4-b]Indole Derivatives, Increase Exercise Performance in Rats and Mice

The actoptrotective activity of 12 new antihypoxants of the thiasolo[5,4-b]indole series was studied on the model of treadmill running until exhaustion 1 and 24 h after intraperitoneal injection. Highly active compounds more effective than the reference drugs bemithyl and phenamine were found. They increased exercise performance 1 or 24 h after injection or maintained high performance throughout 24 h.

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References

  1. 1.

    V. V. Marysheva and P. D. Shabanov, Eksp. Klin. Farmakol., 68, No. 1, 67–70 (2005).

    PubMed  CAS  Google Scholar 

  2. 2.

    V. V. Marysheva, P. D. Shabanov, and A. I. Gavrev, Psikhofarmakol. Biol. Narkol., 6, No. 4, 1351–1354 (2006).

    Google Scholar 

  3. 3.

    V. V. Marysheva, P. A. Torkunov, and P. D. Shabanov, Byull. Eksp. Biol. Med., 141, No. 4, 418–422 (2006).

    Article  Google Scholar 

  4. 4.

    V. V. Marysheva, Obzor. Klin. Farmakol. Lek. Ter., 5, No. 1, 17–26 (2007).

    Google Scholar 

  5. 5.

    Manual of Experimental (Preclinical) Studies of New Drugs [in Russian], Moscow (2000), pp. 153–158.

  6. 6.

    N. N. Samoilov, E. N. Stratienko, F. N. Tseeva, et al., Vestn. Mezhdunar. Akad. Nauk Ekol. Bezopasn. Zhiznedeyat., No. 5, 189–191 (2002).

  7. 7.

    A. B. Tomchin, V. S. Velezheva, and E. B. Shustov, Khim.-Farm. Zh., 32, No. 1, 22–26 (1998).

    CAS  Google Scholar 

  8. 8.

    P. D. Shabanov, Psychopharmacology [in Russian], St. Petersburg (2008).

  9. 9.

    P. D. Shabanov, A. I. Vislobokov, V. V. Marysheva, and K. N. Mel’nikov, Vestn. Ros. Voen.-Med. Akad., No. 1, 67–78 (2005).

    Google Scholar 

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Correspondence to P. D. Shabanov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 1, pp. 58-61, January, 2009

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Marysheva, V.V., Shabanov, P.D. Antihypoxants, Thiasolo[5,4-b]Indole Derivatives, Increase Exercise Performance in Rats and Mice. Bull Exp Biol Med 147, 55–58 (2009). https://doi.org/10.1007/s10517-009-0450-1

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Key Words

  • antihypoxants
  • physical performance
  • thiasolo[5,4-b]indole
  • phenamine
  • bemithyl