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Potentialities of Differential Immunohistochemical Diagnosis of Some Follicular Tumors of the Thyroid Gland

  • Oncology
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Bulletin of Experimental Biology and Medicine Aims and scope

Differential diagnosis of thyroid follicular adenomas, follicular cancer, and papillary cancer with follicular structure was carried out. Proliferation coefficients, probability of atypia, and tumor growth activity were evaluated on the basis of quantitative proportions of proliferation and apoptosis genes expression, derived from indexes of labeled nuclei expressing Ki-67, bcl2, p53 and cytoplasm with expression of bcl2, p53 in cells of these tumors. Significant differences between all the studied tumors of the thyroid grand with follicular structure were detected. The proposed criteria supplement the postoperative morphological differential diagnosis of thyroid tumors.

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References

  1. A. Yu. Abrosimov, Arkh. Patol., No. 1, 64–69 (1997).

  2. Yu. K. Batoroev and K. Yu. Batoroev, Novosti Klin. Tsitol. Rossii, 8, Nos. 3–4, 48–49 (2004).

    Google Scholar 

  3. N. T. Raikhlin and A. N. Raikhlin, Vopr. Onkol., 48, No. 2, 159–171 (2002).

    Google Scholar 

  4. S. L. Asa, Endocr. Pathol., 16, No. 4, 295–309 (2005).

    Article  PubMed  Google Scholar 

  5. P. Farid, S. Z. Gomb, I. Peter, and B. Szende, Neoplasma, 48, No. 4, 299–301 (2001).

    PubMed  CAS  Google Scholar 

  6. Y. Ito, H. Yoshida, C. Tomoda, et al., Pathology, 37, No. 4, 296–298 (2005).

    Article  PubMed  CAS  Google Scholar 

  7. B. K. Kinder, Curr. Opin. Oncol., 15, No. 1, 71–77 (2003).

    Article  PubMed  Google Scholar 

  8. K. P. Letsas, M. Frangou-Lazaridis, A. Skyrlas, et al., Pathol. Int., 55, No. 11, 694–702 (2005).

    Article  PubMed  CAS  Google Scholar 

  9. V. Maximo, J. Lima, P. Soares, et al., Mitochondrion, 5, No. 5, 333–340 (2005).

    Article  PubMed  CAS  Google Scholar 

  10. S. Rezk and A. Khan, Appl. Immunohistochem. Mol. Morphol., 13, No. 3, 256–264 (2005).

    Article  PubMed  Google Scholar 

  11. R. T. Schlinkert, J. A. van Heerden, R. Goellner, et al., Mayo Clin. Proc., 72, No. 10, 913–916 (1997).

    Article  PubMed  CAS  Google Scholar 

  12. G. M. Sclabas, G. A. Staerkel, S. E. Shapiro, et al., Am. J. Surg., 186, No. 6, 702–709 (2003).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Research Center of Clinical and Experimental Medicine, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia

    T. L. Poloz & V. A. Shkurupiy

Authors
  1. T. L. Poloz
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  2. V. A. Shkurupiy
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Correspondence to V. A. Shkurupiy.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Suppl. 1, pp. 49–51, 2008

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Poloz, T.L., Shkurupiy, V.A. Potentialities of Differential Immunohistochemical Diagnosis of Some Follicular Tumors of the Thyroid Gland. Bull Exp Biol Med 146, 794–796 (2008). https://doi.org/10.1007/s10517-009-0419-0

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  • DOI: https://doi.org/10.1007/s10517-009-0419-0

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