Tuberculous granulomas were found in all parenchymal organs of mice infected with mycobacteria of BCG vaccine. The number and size of hepatic granulomas decreased, while the count of degenerated and necrobiotic hepatocytes in infected animals increased 3 months after the start of therapy with a composition of isoniazid and dialdehyde dextran. The composition of isoniazid and dialdehyde dextran obtained by radiochemical oxidation of dextran had greater therapeutic efficacy and lower hepatotoxicity.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Suppl. 1, pp. 73–75, 2008
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Shkurupiy, V.A., Shklovchik, O.V. & Troitskii, A.V. Therapeutic Efficacy and Hepatotoxicity of a Composition of Isoniazid and Dialdehyde Dextran Obtained by Radiochemical Oxidation of Dextran. Bull Exp Biol Med 146, 823–825 (2008). https://doi.org/10.1007/s10517-009-0412-7
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DOI: https://doi.org/10.1007/s10517-009-0412-7