The therapeutic efficacy of a composition of amphotericin B and dialdehyde dextran was much higher than that of amphotericin B in the therapy for systemic candidiasis. This conclusion was derived from the earlier and progressive decrease in the numberand size of candidal granulomas in the kidneys. The composition of amphotericin B and dialdehyde dextran was more potent than amphotericin B in decreasing the nephrotoxiceffect of C. albicans. The opposite strains of CBA and C57Bl/6 mice differed in morphologicalsigns of granulomatosis in the kidneys, but not in the nephrotoxic effect of C. albicans metabolites.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 12, Suppl. 1, pp. 76–79, December, 2008
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Pristavka, A.A., Nadeev, A.P., Travin, M.A. et al. Therapeutic Efficacy of a Composition of Amphotericin B and Dialdehyde Dextran in Kidney Damage in Mice of Various Strains with Systemic Candidiasis. Bull Exp Biol Med 146, 826–828 (2008). https://doi.org/10.1007/s10517-009-0409-2
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DOI: https://doi.org/10.1007/s10517-009-0409-2