Effect of antifungal preparation amphotericin B and its lysosomotropic composition with dialdehyde-dextran on functional state of phagocytizing cells in the dynamics of granulomatous inflammation induced by C. albicans was studied on CBA mice. A stimulating effect of amphotericin B on the production of reactive oxygen species by peritoneal and bone marrow phagocytes was observed, while lysosomotropic form of the antibiotic did not stimulate generation of oxygen radicals.
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References
E. D. Goldberg, A. M. Dygai, and V. P. Shakhov, Methods of Tissue Culture in Hematology [in Russian], Tomsk (1992).
V. V. Kurilin, D. D. Tsyrendorzhiev, Kh. Ts, Dalaeva, et al., Probl. Med. Mikol., 8, No. 2, 56 (2006).
D. N. Mayanskii, Chronic Inflammation [in Russian], Moscow (1991).
A. Yu. Sergeev and Yu. V. Sergeev, Candidosis. Infection Nature, Mechanisms of Aggression and Defense, Laboratory Diagnosis, Clinical Picture, and Therapy [in Russian], Moscow (2001).
O. K. Khmel’nitskii and V. L. Belyanin, Arkh. Pathol., No. 1, 82–85 (1993).
V. A. Shkurupiy, Probl. Med. Mikol., 6, No. 2, 133 (2004).
V. A. Shkurupiy, T. G. Chernova, and Yu. N. Kurunov, Probl. Tub., No. 1, 38–41 (1993).
V. A. Shkurupiy, T. G. Chernova, and Yu. N. Kurunov, Ibid., No. 1, 40–42 (1994).
M. A. Carlson and R. E. Condon, J. Am. Coll. Surg., 179, No. 3, 361–363 (1994).
J. K. Chia and E. J. McManus, Antimicrob. Agents Chemother., 34, No. 5, 906–908 (1990).
J. D. Cleary, S. W. Chapman, and R. L. Nolan, Ibid., 36, No. 5, 977–981 (1992).
B. E. Cohen, Int. J. Pharm., 162, Nos. 1–2, 95–106 (1998).
S. Hardman, I. Stephenson, D. R. Jenkins, et al., J. Immunol., 51, No. 3, e73–e77 (2005).
T. Tono-Oka, N. Ueno, T. Matsumoto, et al., Clin. Immunol. Immunopathol., 26, No. 1, 66–75 (1983).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Suppl. 1, pp. 13–15, 2008
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Kurilin, V.V., Saperova, M.A., Efanov, E.A. et al. Effect of Lysosomotropic Form of Amphotericin B on Functional State of Phagocytes in Experimental Candidiasis. Bull Exp Biol Med 146, 698–700 (2008). https://doi.org/10.1007/s10517-009-0397-2
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DOI: https://doi.org/10.1007/s10517-009-0397-2