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Content of Steroid Hormones in the Blood and Adrenal Glands of Mice in the Dynamics of BCG- and SiO2-Induced Granulomatous Inflammation

  • General Pathology and Pathophysiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Individual or combined administration of BCG vaccine and silicon dioxide to male mice induced a nonspecific stress response of the adrenal glands and gonads judging from changes in the concentration of blood cortisol and testosterone. The dynamics of cortisol concentration in the adrenal glands was similar, while changes in progesterone concentration were in antiphase to those in the blood. After combined administration of both inductors of granulomatous inflammation, changes in the concentrations of the studied hormones to a greater extent corresponded to their dynamics after injection of BCG.

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Authors and Affiliations

  1. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    N. A. Palchikova, O. I. Kuzminova, N. V. Utkina, V. G. Selyatitskaya & V. A. Shkurupiy

Authors
  1. N. A. Palchikova
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  2. O. I. Kuzminova
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  3. N. V. Utkina
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  4. V. G. Selyatitskaya
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  5. V. A. Shkurupiy
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Corresponding author

Correspondence to N. A. Palchikova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Suppl. 1, pp. 20-22, 2008

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Palchikova, N.A., Kuzminova, O.I., Utkina, N.V. et al. Content of Steroid Hormones in the Blood and Adrenal Glands of Mice in the Dynamics of BCG- and SiO2-Induced Granulomatous Inflammation. Bull Exp Biol Med 146, 705–707 (2008). https://doi.org/10.1007/s10517-009-0396-3

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  • DOI: https://doi.org/10.1007/s10517-009-0396-3

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