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Functional State of Adrenocortical System in Rats with Manifest Alloxan-Induced Diabetes Mellitus

  • General Pathology and Pathophysiology
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Bulletin of Experimental Biology and Medicine Aims and scope

In the adrenals of male rats with manifest form of alloxan-induced diabetes mellitus (blood glucose >20 mmol/liter), the content of progesterone was higher by 1.6 times, deoxycorticosterone by 2.5 times, corticosterone by 3.3 times, and 11-dehydrocorticosterone by 1.8 times than in the adrenals of control animals. Increased concentration of corticosterone and 11-dehydrocorticosterone were also found in the serum of rats with alloxan diabetes, but the difference between the experimental and control groups by these parameters was less pronounced compared to parameters in the adrenal glands.

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References

  1. G. Yu. Babadzhanova, Ter. Arkhiv, No. 3, 93–96 (2005).

  2. L. I. Velikanova, Z. R. Shafigullina, N. V. Vorokhobina, et al., Probl. Endokrinol., No. 6, 9–12 (2005).

  3. N. K. Mazurina, Ibid., No. 2, 29–34 (2007).

  4. N. P. Mertvetsov, Hormonal Regulation of Gene Expression [in Russian], Moscow (1986).

  5. N. A. Palchikova, Yu. V. Lutov, L. A. Obukhova, and V. G. Selyatitskaya, Byull. Sib. Otd. Ross. Akad. Med. Nauk., No. 2, 114–118 (2007).

  6. O. P. Cherkasova, Biomed. Khim., No. 6, 568–575 (2006).

  7. O. P. Cherkasova, Byull. Eksp. Biol. Med., 141, No. 1, 35–37 (2006).

    Article  Google Scholar 

  8. O. P. Cherkasova and V. I. Fedorov, Probl. Endokrinol., No. 1, 37–39 (2001).

  9. O. Chan, S. Chan, and K. Inouye, Diabetes, 51, 1681–1689 (2002).

    Article  PubMed  CAS  Google Scholar 

  10. O. Chan, K. Inouye, and M. Vranic, Endocrinology, 143, 1761–1768 (2002).

    Article  PubMed  CAS  Google Scholar 

  11. B. Fruehwald-Schultes, W. Kern, J. Born, et al., Int. J. Obesity, 25, Suppl. 1, S38–S40 (2001).

    Article  Google Scholar 

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Authors and Affiliations

  1. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    V. G. Selyatitskaya, T. V. Pankina & N. A. Palchikova

  2. Institute of Laser Physics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    O. P. Cherkasova

Authors
  1. V. G. Selyatitskaya
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  2. O. P. Cherkasova
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  3. T. V. Pankina
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  4. N. A. Palchikova
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Corresponding author

Correspondence to V. G. Selyatitskaya.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Suppl. 1, pp. 23–25, 2008

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Selyatitskaya, V.G., Cherkasova, O.P., Pankina, T.V. et al. Functional State of Adrenocortical System in Rats with Manifest Alloxan-Induced Diabetes Mellitus. Bull Exp Biol Med 146, 708–710 (2008). https://doi.org/10.1007/s10517-009-0393-6

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  • DOI: https://doi.org/10.1007/s10517-009-0393-6

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