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Reactivity of Airway Phagocytes during the Development of Acute Pneumonia under Conditions of Stimulation of Mononuclear Phagocyte System with Zymosan

  • General Pathology and Pathophysiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Pneumonia was induced in (CBA×C57Bl)F1 mice under conditions of stimulation of the mononuclear phagocyte system with zymosan. The number of neutrophils in airways increased after 3 days; by day 14, the number of cells in the bronchoalveolar lavage fluid further increased due to migration of macrophages. After zymosan prestimulation, the number and functional activity of neutrophils during the early period of inflammation (3 days) did not change, but the increase in phagocytic activity of macrophages was inhibited by 20%. By day 14, the effect of prestimulation manifested in 4.5-fold decreased capacity of neutrophils and macrophages to reduce NBT.

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Authors and Affiliations

  1. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    O. P. Makarova

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  1. O. P. Makarova
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Correspondence to O. P. Makarova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Suppl. 1, pp. 35–38, 2008

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Makarova, O.P. Reactivity of Airway Phagocytes during the Development of Acute Pneumonia under Conditions of Stimulation of Mononuclear Phagocyte System with Zymosan. Bull Exp Biol Med 146, 719–722 (2008). https://doi.org/10.1007/s10517-009-0389-2

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  • DOI: https://doi.org/10.1007/s10517-009-0389-2

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