Activities of sphingomyelinase and ceramidase decreased in the liver in chronic toxic hepatitis and the balance between the levels of proapoptotic ceramide and antiapoptotic sphyngosine-1-phosphate shifts towards the latter substance. Pronounced changes in the qualitative and quantitative composition of fatty acids in the sphingomyelin cycle effector molecules were revealed.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 146, No. 12, pp. 634–637, December, 2008
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Serebrov, V.Y., Kuzmenko, D.I., Burov, P.G. et al. Functional Activity of Sphingomyelin Cycle in Rat Liver in Chronic Toxic Hepatitis. Bull Exp Biol Med 146, 726–729 (2008). https://doi.org/10.1007/s10517-009-0387-4
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DOI: https://doi.org/10.1007/s10517-009-0387-4