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Perinatal Hypoxic and Ischemic Damage to the Central Nervous System Causes Changes in the Expression of Connexin 43 and CD38 and ADP-Ribosyl Cyclase Activity in Brain Cells

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

The expression of connexin 43 and CD38 and ADP ribosyl cyclase activity in brain cells were studied in rats with experimental hypoxic and ischemic damage to the CNS. Changes in the expression and activity of the enzyme were detected over the course of ischemic injury indicating a possible contribution of NAD+-converting activity and NAD+-transporting processes to the pathogenesis of acute cerebral ischemic injury.

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Authors and Affiliations

  1. Department of Biochemistry with Courses of Medical, Pharmaceutical, and Toxicological Chemistry, Krasnoyarsk State Medical Agency, Federal Agency for Public Health and Social Development, Krasnoyarsk, Russia

    A. B. Salmina, N. A. Malinovskaya & S. V. Mikhutkina

  2. Department of Childhood Diseases No. 1, Krasnoyarsk State Medical Agency, Federal Agency for Public Health and Social Development, Krasnoyarsk, Russia

    O. S. Okuneva, T. E. Taranushenko & A. V. Morgun

  3. Institute of Molecular Medicine and Pathological Biochemistry, Krasnoyarsk State Medical Agency, Federal Agency for Public Health and Social Development, Krasnoyarsk, Russia

    A. A. Fursov

  4. Department of Nervous Diseases, Krasnoyarsk State Medical Agency, Federal Agency for Public Health and Social Development, Krasnoyarsk, Russia

    S. V. Prokopenko

  5. Department of Pathological Anatomy, Krasnoyarsk State Medical Agency, Federal Agency for Public Health and Social Development, Krasnoyarsk, Russia

    L. D. Zykova

Authors
  1. A. B. Salmina
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  2. N. A. Malinovskaya
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  3. O. S. Okuneva
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  4. T. E. Taranushenko
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  5. A. A. Fursov
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  6. S. V. Mikhutkina
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  7. A. V. Morgun
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  8. S. V. Prokopenko
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  9. L. D. Zykova
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Corresponding author

Correspondence to A. B. Salmina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 146, No. 12, pp. 641–645, December, 2008

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Salmina, A.B., Malinovskaya, N.A., Okuneva, O.S. et al. Perinatal Hypoxic and Ischemic Damage to the Central Nervous System Causes Changes in the Expression of Connexin 43 and CD38 and ADP-Ribosyl Cyclase Activity in Brain Cells. Bull Exp Biol Med 146, 733–736 (2008). https://doi.org/10.1007/s10517-009-0385-6

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  • DOI: https://doi.org/10.1007/s10517-009-0385-6

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