We studied the role of cardiac glycosides in the regulation of the growth of retinal tissue explants from 10–12-day-old chicken embryos in organotypic culture. The studied compounds produced a dose-dependent effect on cell proliferation in retinal tissue explants. Ouabain (10−13 M), strophanthin K (10−13 M) and digoxin (10−11 M) significantly stimulated explant growth. It was hypothesized that the physiological role of endogenous oubain is associated with regulation of tissue modeling.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 146, No. 12, pp. 651-653, December, 2008
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Lopatina, E.V., Karetsky, A.V., Penniyaynen, V.A. et al. Role of Cardiac Glycosides in Regulation of the Growth of Retinal Tissue Explants. Bull Exp Biol Med 146, 744–746 (2008). https://doi.org/10.1007/s10517-009-0384-7
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DOI: https://doi.org/10.1007/s10517-009-0384-7