Comparative study of experimental kinetics of distribution of benzimidazole derivatives (bemithyl, etomerzole, and thietazole) in organs and tissues was carried out after single and course treatment. The drugs intensely passed into organs and tissues from the blood after treatment by all protocols. Specific features of drug distribution were detected; for example, splenic tissue selectively accumulated thietazole during course treatment.
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References
V. A. Myshkin, A. I. Savlukov, I. L. Gulyaeva, et al., Obshchaya Reanimatol., 3, Nos. 5–6, 69–74 (2007).
S. A. Sergeeva and I. L. Gulyaeva, Byull. Eksp. Biol. Med., 141, No. 5, 534–536 (2006).
S. A. Sergeeva and I. L. Gulyaeva, Ibid., 145, No. 1, 47–49 (2008).
V. N. Solovyov, A. A. Firsov, and V. A. Filov, Pharmacokinetics [in Russian], Moscow (1980).
A. A. Spasov, L. A. Smirnova, I. Ya. Iezhitsa, et al., Vopr. Med. Khim., 48, No. 3, 233–258 (2002).
F. C. Cheng, Y. E. Ho, L. C. Hung, et al., J. Chromatogr. A., 949 1–2, 35–42 (2002).
X. N. Zhang, Q. Zhang, H. Wen, et al., Yao Xue Xue Bao, 38, No. 6, 462–466 (2003).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 146, No. 12, pp. 657–659, December, 2008
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Sergeeva, S.A., Gulyaeva, I.L. Comparative Experimental Pharmacokinetics of Benzimidazole Derivatives. Bull Exp Biol Med 146, 750–752 (2008). https://doi.org/10.1007/s10517-009-0382-9
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DOI: https://doi.org/10.1007/s10517-009-0382-9