Skip to main content
SpringerLink
Log in

Investigation of Changes in NO Content during Long-Term Sensitization in Edible Snail Using EPR-Spectroscopy: Effects of Antibodies to Calcium-Binding Protein S-100

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

EPR-spectroscopy experiments (electron paramagnetic resonance) demonstrated a decrease in NO production in the nervous system and heart of edible snail Helix lucorum after formation of long-term sensitization, a neurobiological model of anxiety and depression. The protective effect of antibodies to Ca2+-binding protein S-100 in dilution of 10−12 on the formation of long-term sensitization was accompanied by partial recovery of NO synthesis in the nervous system and heart. These findings indicate that the imbalance in Ca2+-binding protein S-100 can lead to inhibition or modulation of some processes during plastic reorganization in the body and especially during pathological processes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. P. M. Balaban and I. S. Zakharov, Learning and Development: Common Basis of the Two Events [in Russian], Moscow (1992).

  2. A. F. Vanin, Biokhimia, 63, No. 7, 924–938 (1998).

    Google Scholar 

  3. Kh. L. Gainutdinov and N. A. Beregovoy, Zhurn. Vyssh. Nervn. Deiat., 44, No. 2, 307–315 (1994).

    Google Scholar 

  4. T. L. Diakonova, Ross. Physiol. Zhurn., 84, No. 1, 1152–1160 (1998).

    CAS  Google Scholar 

  5. T. L. Diakonova, Ibid., 86, No. 9, 1210–1219 (2000).

    CAS  Google Scholar 

  6. V. D. Mikoyan, L.N. Kubrina, and A. F. Vanin, Biofizika, 39, 915–918 (1994).

    CAS  Google Scholar 

  7. V. P. Nikitin and S. A. Kozyrev, Ross. Physiol. Zhurn, 45, No. 4, 732–741 (1995).

    CAS  Google Scholar 

  8. G. A. Pavlova, Dokl. Ross. Akad. Nauk, 335, No. 2, 258–260 (1994).

    Google Scholar 

  9. V. P. Reutov, E. G. Sorokina, V. E. Okhotin, N. S. Kositcyn, Cyclic NO Transformations in Mammals [in Russian], Moscow (1998).

  10. A. Kh. Urazaev and A. L. Zefirov, Uspekhi Fiziol. Nauk., 30, No. 1, 54–72 (1999).

    CAS  Google Scholar 

  11. O. I. Epstein, M. B. Shtark, A. Kh. Timoshenko, et al., Byull. Eksp. Biol. Med., 143, No. 5, 490–493 (2007).

    Article  Google Scholar 

  12. E. G. Antzoulatos, M. L. Wainwright, L. J. Cleary, and J. H. Byrne, Learn. Mem., 13, No. 4, 422–425 (2006).

    Article  PubMed  Google Scholar 

  13. C. Erxleben and A. Hermann, Neurosci. Lett., 300, 133–139 (2001).

    Article  PubMed  CAS  Google Scholar 

  14. T. H. Gainutdinova, R. R. Tagirova, A. I. Ismailova, et al., Learn. Mem., 12, No. 6, 620–625 (2005).

    Article  PubMed  Google Scholar 

  15. A. Gelperin, J. Flores, F. Raccuia-Behling, I. R. Cooke, J. Neurophysiol., 83, 116–127 (2000).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. E. K. Zavoiskii Kazan’ Physicotechnical Institute, Russian Academy of Sciences, Novosibirsk, Russia

    Kh. L. Gainutdinov, V. V. Andrianov, T. Kh. Gainutdinova, L. N. Muranova, A. A. Obynochny, A. Kh. Timoshenko, S. V. Yurtaeva & G. G. Jafarova

  2. Research Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    M. B. Shtark

  3. Materia Medica Holding, Moscow, Russia

    O. I. Epstein

Authors
  1. Kh. L. Gainutdinov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. V. Andrianov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Kh. Gainutdinova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. N. Muranova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. A. Obynochny
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Kh. Timoshenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M. B. Shtark
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. O. I. Epstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. S. V. Yurtaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. G. G. Jafarova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kh. L. Gainutdinov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 146, No. 12, pp. 617–622, December, 2008

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gainutdinov, K.L., Andrianov, V.V., Gainutdinova, T.K. et al. Investigation of Changes in NO Content during Long-Term Sensitization in Edible Snail Using EPR-Spectroscopy: Effects of Antibodies to Calcium-Binding Protein S-100. Bull Exp Biol Med 146, 675–679 (2008). https://doi.org/10.1007/s10517-009-0367-8

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-009-0367-8

Key Words

Search

Navigation