Study of the effects of 2- and 10-min acupuncture on skin structures in acupuncture points on the upper limb and trunk of outbred albino rats showed that changes in the monoamine status of the skin appeared as early as 15 min after acupuncture. However, the effects in points GV14 and LI11 were different: skin structures in acupuncture point LI11 reacted sooner and more intensively. Acupuncture caused opposite changes in the serotonin index in different structures of the skin in acupuncture points.