Pyloric stenosis and pancreatitis were simulated before and after administration of serotonin and spiperone (5-HT2 receptor blocker). Activation of the serotoninergic system prevented the development of pancreatitis, but led to more severe course of pyloric stenosis.
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L. B. Lazebnik and A. E. Lychkova, Byull. Eksp. Biol. Med., 141, No. 1, 8–12 (2006).
A. E. Lychkova, Ibid., 134, No. 8, 237–240 (2002).
A. D. Nozdrachev and A. D. Polyakov, Rat Anatomy [in Russian], St. Petersburg (2001).
V. I. Ovsyannikov, Neuromediators and Hormones in the Gastrointestinal Tract [in Russian], Moscow (2003).
N. S. Tropskaya, Byull. Eksp. Biol. Med., 140, No. 9, 247–249 (2005).
R. Pakala, J. T. Willerson, and C. R. Benedict, Circulation, 90, No. 4, 1919–1926 (1994).
S. Vanner and A. Surprenant, Br. J. Pharmacol., 99, No. 4, 840–844 (1990).
P. R. Wade, G. M. Mawe, T. A. Branchek, and M. D. Gershon, Am. J. Physiol., 260, No. 1, Pt. 1, G80–G90 (1991).
T. Yoshino and I. Yamaguchi, J. Pharmacol. Exp. Ther., 283, No. 3, 1495–1502 (1997).
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 8, pp. 226–232, August, 2008
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Lychkova, A.E. Serotoninergic system in the development of pyloric stenosis and pancreatitis. Bull Exp Biol Med 146, 258–263 (2008). https://doi.org/10.1007/s10517-008-0264-6
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DOI: https://doi.org/10.1007/s10517-008-0264-6