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Structural changes in the liver of mice infected with avian influenza virus subtype H5N1

  • Virology
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Bulletin of Experimental Biology and Medicine Aims and scope

Intranasal infection of male outbred rats with isolate of influenza A virus subtype H5N1 (A/Gs/Krasnoozerskoye/627/05) from the Novosibirsk region was followed by high mortality of experimental animals. Morphological study of liver samples revealed subtotal destructive changes in the liver parenchyma (proteinosis and centrolobular necroses), which was related to hemodynamic disorders and cytokine dysregulation. The decrease in reparative activity of hepatocytes was probably followed by hepatocellular failure and contributed to high mortality rate from this infection (up to 85%).

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Authors and Affiliations

  1. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    T. V. Sharkova, O. V. Potapova & V. A. Shkurupy

  2. State Research Center of Virology and Biotechnology “Vector”, Federal Service on Surveillance for Consumer Rights Protection and Human Well-being, Novosibirsk region, Kol’tsovo, Russia

    A. M. Shestopalov & I. G. Drozdov

  3. Department of Physiology, Novosibirsk State University, Novosibirsk, Russia

    L. V. Shestopalova

Authors
  1. T. V. Sharkova
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  2. O. V. Potapova
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  3. V. A. Shkurupy
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  4. A. M. Shestopalov
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  5. I. G. Drozdov
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  6. L. V. Shestopalova
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Corresponding author

Correspondence to T. V. Sharkova.

Additional information

Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 8, pp. 210–212, August, 2008

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Sharkova, T.V., Potapova, O.V., Shkurupy, V.A. et al. Structural changes in the liver of mice infected with avian influenza virus subtype H5N1. Bull Exp Biol Med 146, 243–245 (2008). https://doi.org/10.1007/s10517-008-0262-8

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  • DOI: https://doi.org/10.1007/s10517-008-0262-8

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