The expression of mRNA of proteins involved in the transformations of cytostatics (cytochrome P-450 1A1 and 1B1 isoforms) and genes encoding proteins participating in their regulation (Ah receptor, AHRR and ARNT) in intestinal tumors and intact portions of the intestine were studied. The expression of cytochrome P-450 1A1 increased in poorly differentiated tumors in comparison with its expression in intact portions of the intestine (tumor/intact tissue=1.65). The expression of cytochrome P-450 1B1 was higher in well-differentiated tumors (tumor/intact tissue=1.62). The possibility of practical use of high expression of cytochrome P-450 isoforms in tumors in comparison with intact intestinal tissue is discussed.
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Referenecs
E. Brantley, V. Trapani, M. C. Alley, et al., Drug Met. Dispos., 32, No. 12, 1392–1401 (2004).
K. M. L. Crommentuyn, J. H. M. Schellens, J. D. van der Berg, and J. H. Beijnen, Cancer Treat. Rev., 24, 345–366 (1998).
M. S. Chua, E. Kashiyama, T. D. Bradshaw, et al., Cancer Res., 60, No. 18, 5196–5203 (2000).
S. Haas, C. Pierl, V. Harth, et al., Int. J. Cancer, 119, No. 8, 1785–1791 (2006).
P. A. Harper, B. K. Tang, and A. B. Okey, Biochem. Pharmacol., 56, No. 5, 599–612 (1998).
E. C. Henry, J. C. Bemis, O. Henry, et al., Arch. Biochem. Biophys., 450, No. 1, 67–77 (2006).
P. Gibson, J. Gill, P. Khan, et al., Mol. Cancer Therapeut., No. 2, 527–534 (2003).
M. J. Kuffel, J. C. Schroeder, L. J. Pobst, et al., Mol. Pharmacol., 62, No. 1, 143–153 (2002).
M. Kumarakulasingham, P. H. Rooney, S. R. Dundas, and C. Tefler, Clin. Cancer Res., 11, No. 10, 3758–3765 (2005).
M. C. McFadyen, W. T. Melvin, and G. I. Murray, Mol. Cancer Ther., 3, No. 3, 363–371 (2004).
H. Raunio, R. Juvonen, M. Pasanen, et al., Hepatology, 27, No. 2, 427–432 (1998).
S. Roblin, A. B. Okey, and P. A. Harper, Biochem. Biophys. Res. Commun., 317, No. 1, 142–148 (2004).
V. Trapani, V. Patel, C. O. Leong, and H. P. Ciolino, Br. J. Cancer, 88, No. 4, 599–605 (2003).
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 8, pp. 217–220, August, 2008
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Evteev, V.A., Barsukov, J.A., Aliev, V.I. et al. Comparative analysis of family 1 cytochrome P-450 mRNA expression in human intestinal adenocarcinoma and intact portion of the intestine. Bull Exp Biol Med 146, 250–253 (2008). https://doi.org/10.1007/s10517-008-0261-9
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DOI: https://doi.org/10.1007/s10517-008-0261-9