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Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Simvaglyzin, a complex compound of simvastatin and glycyrrhizic acid, administered to rabbits with experimental hypercholesterolemiain in doses equivalent to 66.6 and 40 µg/kg simvastatin exhibited antioxidant capacity (decreased the content of lipid peroxidation products in the blood by 27–41%) and endothelium-normalizing effect (decreased the level of von Willebrand factor and endothelin-1 by 26–58 and 21–29%, respectively, compared to 200 µg/kg simvastatin, p<0.05).

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Authors and Affiliations

  1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    N. F. Salakhutdinov & G. A. Tolstikov

  2. Institute of Therapy, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    Yu. I. Ragino, E. M. Stakhneva & Yu. P. Nikitin

  3. Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    V. A. Vavilin, S. I. Makarova, O. G. Safronova & V. V. Lyakhovich

Authors
  1. Yu. I. Ragino
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  2. V. A. Vavilin
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  3. N. F. Salakhutdinov
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  4. S. I. Makarova
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  5. E. M. Stakhneva
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  6. O. G. Safronova
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  7. V. V. Lyakhovich
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  8. Yu. P. Nikitin
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  9. G. A. Tolstikov
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Additional information

Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 8, pp. 171–174, August, 2008

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Ragino, Y.I., Vavilin, V.A., Salakhutdinov, N.F. et al. Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia. Bull Exp Biol Med 146, 206–209 (2008). https://doi.org/10.1007/s10517-008-0252-x

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  • DOI: https://doi.org/10.1007/s10517-008-0252-x

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