Painful reaction of rats to intraperitoneal injections of L-arginine, Nω-nitro-L-arginine, and agmatine was studied on the model of formalin-induced inflammation. All drugs exhibited a dubious effect on the patterns of nociceptive behavior depending on the phase of painful reaction. The dynamics of nitrate/nitrite content in animal blood and serum indicated the presence of NO-dependent and NO-independent components in the mechanisms of pharmacological effects of these drugs.
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 8, pp. 179–182, August, 2008
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Dyuizen, I.V., Lamash, N.E. Effects of NO-modulating agents on the development of acute painful reaction in rats. Bull Exp Biol Med 146, 214–217 (2008). https://doi.org/10.1007/s10517-008-0250-z
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DOI: https://doi.org/10.1007/s10517-008-0250-z