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Intrastrial injection of magnesium after picrotoxin does not reduce motor hyperactivity in rats

  • Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Magnesium chloride injected into rat rostral neostriatum before picrotoxin prevents motor hyperactivity induced by this GABAA receptor antagonist: prevents the increase in spontaneous motor activity in the open field test and reduces reproduction and duration of choreic hyperkinesia. Injection of magnesium 15 min after picrotoxin virtually did not modify the hyperkinetic effects of picrotoxin. The results indicate the role of calcium processes in the appearance of strial picrotoxin hyperactivity and principal possibility of its correction with magnesium only before the cascade of respective calcium ionic transformations is triggered in the brain.

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References

  1. V. M. Varshavskaya and A. F. Yakimovskii, Byull. Eksp. Biol. Med., 140, No. 11, 500–503 (2005).

    Google Scholar 

  2. S. N. Illarioshkin, Conformation Diseases of the Brain [in Russian], Moscow (2003).

  3. A. F. Yakimovskii, Byull. Eksp. Biol. Med., 114, No. 1, 7–9 (1993).

    Google Scholar 

  4. A. F. Yakimovskii and V. M. Varshavskaya, Med. Akad. Zh., 6, No. 2, 28–40 (2006).

    Google Scholar 

  5. A. F. Yakimovskii and V. M. Varshavskaya, Ros. Fiziol. Zh., 92, No. 6, 723–731 (2006).

    CAS  Google Scholar 

  6. N. A. Dorofeeva, D. B. Tikhonov, O. I. Barygin, et al., J. Neurochem., 95, No. 6, 1704–1712 (2005).

    Article  PubMed  CAS  Google Scholar 

  7. L. V. Metman, M. J. Morris, C. Farmer, et al., Neurology, 59, No. 5, 694–699 (2002).

    CAS  Google Scholar 

  8. Ch. A. Ross and R. L. Margolis, Neuropsychopharmacology: the Fifth Generation of Progress, Eds. K. L. Davis et al., New York (2002), pp. 1817–1830.

  9. T. Voets, A. Janssens, J. Prener, et al., J. Gen. Physiol., 121, No. 3, 245–260 (2003).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Normal Physiology, I. P. Pavlov St. Petersburg State Medical University, St. Petersburg, Russia

    A. F. Yakimovskii, V. M. Varshavskaja & A. L. Yakubenko

  2. Laboratory of Physiology of Higher Nervous Activity, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    A. F. Yakimovskii, V. M. Varshavskaja & A. L. Yakubenko

Authors
  1. A. F. Yakimovskii
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  2. V. M. Varshavskaja
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  3. A. L. Yakubenko
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Corresponding author

Correspondence to A. F. Yakimovskii.

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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 8, pp. 128–130, August, 2008

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Yakimovskii, A.F., Varshavskaja, V.M. & Yakubenko, A.L. Intrastrial injection of magnesium after picrotoxin does not reduce motor hyperactivity in rats. Bull Exp Biol Med 146, 165–167 (2008). https://doi.org/10.1007/s10517-008-0241-0

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  • DOI: https://doi.org/10.1007/s10517-008-0241-0

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