We compared activity of synthetic complexes of angiotensin II and functionally different proteins (transport protein, serum albumin and neurospecific Ca2+-binding protein S100b) as analogues of endogenous protein-peptide complexes. Physiological activity of angiotensin II was specifically modified by these proteins. It was hypothesized that the complex of angiotensin II and S100b is primarily involved in the regulation of hemodynamics, whereas the complex of angiotensin II and bovine serum albumin plays a role in the formation and realization of drinking behavior.
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References
A. V. Kotov, S. M. Tolpygo, E. I. Pevtsova, and M. F. Obukhova, Vestn. Ros. Akad. Med. Nauk, No. 4, 36–43 (2001).
J. L. Aldons, Nature, 407, 233–241 (2000).
D. Daniels, D. K. Yee, L. F. Faulconbridge, and S. J. Fluharty, Endocrinology, 146, No. 12, 5552–5560 (2005).
B. Farsak, S. Gunaydin, C. Yorgancioglu, and Y. Zorlutuna, Cardiovasc. Surg. (Torino), 44, No. 1, 31–35 (2003).
L. Hunyady and K. J. Catt, Mol. Endocrinol., 20, No. 5, 953–970 (2006).
M. Kurdi, W. C. De Mello, and G. W. Booz, Intern. J. Biochem. Cell Biol., 37, No. 7, 1357–1367 (2005).
T. Mello e Souza, A. Rohden, M. Meinhardt, et al., Physiol. Behav., 71, No. 1–2, 29–33 (2000).
D. Menta and A. B. Malik, Physiol. Rev., 86, 279–367 (2006).
H. Nishiyama, T. Knopfel, S. Endo, and S. Itohara, Proc. Natl. Acad. Sci. USA, 99, No. 6, 4037–4042 (2002).
E. Savaskan, Curr. Alzheim. Res., 2, No. 1, 29–35 (2005).
M. L. Schroeter, H. Abdul-Khaliq, A. Diefenbacher, and I. E. Blasig, Neuroreport, 13, No. 13, 1675–1688 (2002).
B. S. Shastry, Neurochem. Int., 43, No. 1, 1–7 (2003).
V. V. Sherstnev, M. A. Gruden', Z. I. Storozheva, and A. T. Proshin, Neurosci. Behav. Physiol., 33, No. 1, 31–38 (2003).
M. Stoppini, A. Andreola, G. Foresti, and V. Bellotti, Pharmacol. Res., 50, No. 4, 419–431 (2004).
S. J. Veerasingham and M. K. Raizada, Br. J. Pharmacol., 139, No. 2, 191–202 (2003).
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 8, pp. 135–138, August, 2008
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Pevtsova, E.I., Tolpygo, S.M., Obukhova, M.F. et al. Physiological effects of complexes of angiotensins with functionally different carrier proteins. Bull Exp Biol Med 146, 172–175 (2008). https://doi.org/10.1007/s10517-008-0240-1
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DOI: https://doi.org/10.1007/s10517-008-0240-1