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  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
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In vitro inhibitory effect of mesenchymal stem cells on zymosan-induced production of reactive oxygen species

Bulletin of Experimental Biology and Medicine volume 146, pages 158–164 (2008)Cite this article

In vitro chemiluminescent test showed that human bone marrow mesenchymal stem cells and conditioned media dose-dependently inhibit production of reactive oxygen species by macrophages: 50% inhibition of chemiluminescence (compared to biocontrol) was observed at 1:1 mesenchymal stem cell/macrophage ratio or after addition of 20–25% conditioned media to the incubation medium. The observed mechanism of inhibition of production of reactive oxygen forms can play an essential role in the formation of local immunosuppressive microenvironment in the organism after allogenic transplantation of mesenchymal stem cells.

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Affiliations

  1. Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, Russia

    A. F. Tsyb, V. N. Petrov, A. G. Konoplyannikov, E. V. Saypina, L. A. Lepechina, S. Sh. Kalsina, I. V. Semenkova & E. V. Agaeva

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  1. A. F. Tsyb
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  2. V. N. Petrov
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  3. A. G. Konoplyannikov
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  4. E. V. Saypina
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  5. L. A. Lepechina
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  6. S. Sh. Kalsina
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  7. I. V. Semenkova
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  8. E. V. Agaeva
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Corresponding author

Correspondence to A. G. Konoplyannikov.

Additional information

Translated from Kletochnye Tehnologii v Biologii i Medicine, No. 3, pp. 171–178, August, 2008

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Tsyb, A.F., Petrov, V.N., Konoplyannikov, A.G. et al. In vitro inhibitory effect of mesenchymal stem cells on zymosan-induced production of reactive oxygen species. Bull Exp Biol Med 146, 158–164 (2008). https://doi.org/10.1007/s10517-008-0238-8

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  • DOI: https://doi.org/10.1007/s10517-008-0238-8

Key Words

  • mesenchymal stem cells
  • macrophages
  • reactive oxygen radicals
  • local immunosuppressive environment