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Induction of antiidiotypic immune response with autologous T-cell vaccine in patients with multiple sclerosis

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
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Bulletin of Experimental Biology and Medicine Aims and scope

Patients with different forms of multiple sclerosis were treated with a vaccine consisting of myelin-reactive T cells. It was found that after this treatment, lymphocytes from patients acquired the capacity to generate antiidiotypic proliferative response directed towards myelin-reactive T cells. The serum concentration of IFN-γ decreased about 2-fold 1.5–2.0 years after the start of vaccine therapy, whereas the concentration of IL-4 increased 2–3 fold. Myelin-reactive proliferative activity of peripheral blood mononuclear cells also decreased. The results of the 2-year follow-up study revealed no side effect of T-cell vaccination in patients with cerebrospinal form of multiple sclerosis and demonstrated its possible clinical efficiency in the treatment of this disease at early stages.

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Authors and Affiliations

  1. Research Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia

    I. P. Ivanova, V. I. Seledtsov, G. V. Seledtsova, S. V. Mamaev, A. V. Potyemkin, D. V. Seledtsov & V. A. Kozlov

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  1. I. P. Ivanova
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  2. V. I. Seledtsov
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  3. G. V. Seledtsova
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  4. S. V. Mamaev
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  5. A. V. Potyemkin
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  6. D. V. Seledtsov
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  7. V. A. Kozlov
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Corresponding author

Correspondence to I. P. Ivanova.

Additional information

Translated from Kletochnye Tehnologii v Biologii i Medicine, No. 3, pp. 145–150, August, 2008

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Ivanova, I.P., Seledtsov, V.I., Seledtsova, G.V. et al. Induction of antiidiotypic immune response with autologous T-cell vaccine in patients with multiple sclerosis. Bull Exp Biol Med 146, 133–138 (2008). https://doi.org/10.1007/s10517-008-0237-9

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  • DOI: https://doi.org/10.1007/s10517-008-0237-9

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