Immune nephritis in rats was induced by administration of nephrotoxic rabbit antiserum. The development of severe renal inflammation (proteinuria, edema, lipemia, increased erythrocyte sedimentation rate, and 30% mortality) was accompanied by hypercoagulation and inhibition of fibrinolysis. Repeated subcutaneous injections of thymoptin in a low dose of 0.1 µg/200 g (5 injections every other day) increased the severity of inflammation and prethrombotic state of the blood. Lengthening the period between injections (5 injections at 5-day intervals) was followed by a tendency toward attenuation of nephritis and correction of hypercoagulation. In healthy rats, thymoptin produced an opposite effect on hemostasis, which was manifested in moderate stimulation of fibrinolysis and hypocoagulation.
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 7, pp. 8–12, July, 2008
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Podorolskaya, L.V., Serebryakova, T.N., Andreenko, G.V. et al. Effect of thymoptin on hemostasis and fibrinolysis in rats with experimental nephritis. Bull Exp Biol Med 146, 4–8 (2008). https://doi.org/10.1007/s10517-008-0228-x
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DOI: https://doi.org/10.1007/s10517-008-0228-x