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Neurotropic effect of exogenous L-carnosine in cultured slices of the olfactory cortex from rat brain

  • Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Incubation of cultured slices of the olfactory cortex from rat brain with L-carnosine in concentrations of 50, 250, and 500 µM induced activation of glutamatergic and GABAB-ergic mechanisms and facilitated long-term posttetanic potentiation. The effect of L-carnosine is mediated by its effect on AMPA-and NMDA-related glutamatergic receptors and on inhibitory GABAB receptors.

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Authors and Affiliations

  1. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    A. X. Khama-Murad, L. I. Pavlinova & A. A. Mokrushin

Authors
  1. A. X. Khama-Murad
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  2. L. I. Pavlinova
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  3. A. A. Mokrushin
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 7, pp. 4–7, July, 2008

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Khama-Murad, A.X., Pavlinova, L.I. & Mokrushin, A.A. Neurotropic effect of exogenous L-carnosine in cultured slices of the olfactory cortex from rat brain. Bull Exp Biol Med 146, 1–3 (2008). https://doi.org/10.1007/s10517-008-0227-y

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  • DOI: https://doi.org/10.1007/s10517-008-0227-y

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