Skip to main content

Advertisement

SpringerLink
Log in

Use of primary human fetal chondroblast culture for xenotransplantation into rat articular cartilage defect

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The possibility of xenotransplantation of human fetal chondroblasts was studied. Filling of the rat articular cartilage defect with a tissue-engineering construction based on primary culture of human fetal chondroblasts and chitosan gel caused no immune rejection over 60 days and provided the formation of organotypical regenerate due to proliferation and differentiation of donor fetal chondroblasts and their integration in the recipient cartilage tissue.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. V. Sakharov, T. D. Kolokoltseva, I. P. Kim, and E. I. Ryabchikova, Klet. Tekhnol. Biol. Med., No. 3, 154–158 (2007).

  2. G. T. Sukhikh, I. M. Bogdanova, and V. V. Malaitseva, Byull. Eksp. Biol. Med., 136, No. 7, 124–129 (2003).

    Google Scholar 

  3. E. T. Bloom, Xenotransplantation, 14, No. 4, 345–346 (2007).

    Article  PubMed  Google Scholar 

  4. K. R. Brodkin and A. J. Garcia, Biomaterials, 25, 5929–5938 (2004).

    Article  PubMed  CAS  Google Scholar 

  5. F. Caumo, A. Russo, and N. Faccioli, Article in English, Italian. Radiol. Med. (Torino), 112, No. 5, 722–731 (2007).

    Article  CAS  Google Scholar 

  6. C. Chanlalit, C. Kasemkijwattanamd, and V. Varavit, J. Med. Assoc. Thai., 90, No. 7, 1435–1442 (2007).

    PubMed  Google Scholar 

  7. E. Cozzi, M. Seveso, and S. Hutabba, Vet. Res. Commun., 11, 15–25 (2007).

    Article  Google Scholar 

  8. S. J. K. Francis and W. T. Howard, Biomaterials, 21, 2589–2598 (2000).

    Article  Google Scholar 

  9. I. Fuentes-Boquete, I. M. Lopez-Armada, E. Maneiro, et al., Wound Rep. Reg., 12, 444–452 (2004).

    Article  Google Scholar 

  10. Y. X. Nakamura and C. Wang, Stem Cells, 25, No. 3, 612–620 (2007).

    Article  PubMed  CAS  Google Scholar 

  11. G. Schulze-Tanzil, P. Souza, and V. Castrejon, Cell Tissue Res., 308, No. 3, 371–379 (2002).

    Article  PubMed  CAS  Google Scholar 

  12. J. S. Tamenoff and A. G. Mikos, Biomaterials, 21, 431–440 (2000).

    Article  Google Scholar 

  13. J. Yan, N. Qi, and Q. Zhang, Art. Cells Blood Sub. Immobil. Biotechnol., 35, No. 4, 333–344 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Morphology, Novosibirsk State Pedagogical University, Novosibirsk, Russia

    A. V. Sakharov, A. A. Makeyev, S. N. Lukanina, M. B. Pykhtina & E. I. Ryabchikova

  2. L. A. Tarasevich Institute of Standardization and Control of Medical Biological Preparations, Moscow, Russia

    T. D. Kolokoltseva

  3. Novosibirsk State Medical University, Novosibirsk, Russia

    A. V. Efremov, V. A. Valeyeva & L. G. Burova

Authors
  1. A. V. Sakharov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. A. Makeyev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. V. Efremov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. A. Valeyeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. G. Burova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. T. D. Kolokoltseva
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S. N. Lukanina
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. M. B. Pykhtina
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. E. I. Ryabchikova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. V. Sakharov.

Additional information

Translated from Kletochnye Tehnologii v Biologii i Medicine, No. 3, pp. 136–140, August, 2008

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sakharov, A.V., Makeyev, A.A., Efremov, A.V. et al. Use of primary human fetal chondroblast culture for xenotransplantation into rat articular cartilage defect. Bull Exp Biol Med 146, 124–128 (2008). https://doi.org/10.1007/s10517-008-0220-5

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-008-0220-5

Key Words

Search

Navigation