It is convenient to study liver function and metabolism on the model of isolated perfused organ. The results of the present study indicate that viability and metabolic activity of the organ largely depend on the composition of the medium. Under conditions of isolated perfusion, the known pathway of oxygen transport through capillary filtration is supplemented by oxygen delivery to cells through the organ surface making an important contribution to liver oxygenation.
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 7, pp. 117–120, July, 2008
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Rupenko, A.P., Kruglik, O.V. & Morgulis, I.I. Functional activity of isolated perfused rat liver depends on medium composition. Bull Exp Biol Med 146, 107–110 (2008). https://doi.org/10.1007/s10517-008-0219-y
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DOI: https://doi.org/10.1007/s10517-008-0219-y