Suppression of kininogenesis is an adaptive phenomenon in cerebral ischemia/reperfusion in rats aimed at elimination of the no-reflow phenomenon. Hyperkininogenesis and suppression of kinin destruction are pathogenetically significant, because they augment the manifestations of no-reflow phenomenon during reperfusion following ischemia.
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 7, pp. 30–32, July, 2008
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Orobei, M.V., Kulikov, V.P. & Shatillo, Y.G. Kinin formation in the plasma and cerebral blood flow under conditions of cerebral ischemia/reperfusion in rats during modulation of kinin system activity. Bull Exp Biol Med 146, 26–28 (2008). https://doi.org/10.1007/s10517-008-0199-y
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DOI: https://doi.org/10.1007/s10517-008-0199-y