Abstract
We studied the effects of a new dipeptide with anxiolytic activity (GB-115, N-phenylhexanoyl-glycyl-L-tryptophan amide) on parameters of the immune in intact mice and in animals with secondary immunodeficiency caused by cyclophosphamide. GB-115 in doses of 0.1–10 mg/kg stimulated phagocytic activity of peritoneal macrophages and humoral immune response in intact mice. GB-115 exhibited immunocorrecting activity in animals with secondary immunodeficiency.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 5, pp. 548–551, May, 2008
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Shipaeva, E.V., Kovalenko, L.P., Khaidukov, S.V. et al. Immunocorrecting properties of GB-115 dipeptide. Bull Exp Biol Med 145, 610–613 (2008). https://doi.org/10.1007/s10517-008-0153-z
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DOI: https://doi.org/10.1007/s10517-008-0153-z