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In vivo study of dihydroquercetin genotoxicity

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Genotoxic properties of dihydroquercetin were in vivo studied by the method of chromosome aberrations counting and DNA-comet assay. Dihydroquercetin administered repeatedly (5 times, 0.15 and 1.5 mg/kg) or once in doses of 15, 150, and 2000 mg/kg induced no DNA damages in mouse bone marrow, blood, liver, and rectal cells. Single administration of this preparation in doses of 1.5 and 150 mg/kg and 5-fold administration in a dose of 1.5 mg/kg had no effect on the level of chromosome aberrations in mouse bone marrow cells.

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References

  1. A. D. Durnev and S. B. Seredenin, Mutagens. Screening and Pharmacological Prophylaxis of Effects [in Russian], Moscow (1998).

  2. N. K. Zenkov, N. V. Kandalintsev, V. Z. Lankin, et al., Phenol Bioantioxidants [in Russian], Novosibirsk (2003).

  3. Methodic Recommendations for Evaluation of Mutagenic Properties of Pharmacological Substances. Manual on Experimental Study of New Pharmacological Substances. Moscow (2000), pp. 47–60.

  4. M. B. Plotnikov, N. A. Tyukavkina, and T. M. Plotnikova, Diquertin-Based Drugs [in Russian], Tomsk (2005).

  5. Application of Alkaline Single-Cell Gel-Electrophoresis for Evaluation of Genotoxic Properties of Natural and Synthetic Compounds. Methodical Recommendations [in Russian], Moscow (2006).

  6. J. P. Brown, Mutat. Res., 75, 243–277 (1980).

    PubMed  CAS  Google Scholar 

  7. J. da Silva, S. M. Herrmann, V. Heuser, et al., Food Chem. Toxicol., 40, No. 7, 941–947 (2002).

    Article  PubMed  Google Scholar 

  8. B. Halliwell, Cardiovasc. Res., 73, No. 2, 341–347 (2007).

    Article  PubMed  CAS  Google Scholar 

  9. A. Hartmann, C. Agurell, C. Beevers, et al., Mutagenesis, 18, No. 1, 45–51 (2003).

    Article  PubMed  CAS  Google Scholar 

  10. K. Konca, A. Lankoff, and A. Banasik, Mutat. Res., 534, Nos. 1–2, 15–20 (2003).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia

    A. K. Zhanataev, A. V. Kulakova, V. V. Nasonova & A. D. Durnev

Authors
  1. A. K. Zhanataev
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  2. A. V. Kulakova
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  3. V. V. Nasonova
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  4. A. D. Durnev
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 3, pp. 309–312, March, 2008

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Zhanataev, A.K., Kulakova, A.V., Nasonova, V.V. et al. In vivo study of dihydroquercetin genotoxicity. Bull Exp Biol Med 145, 338–340 (2008). https://doi.org/10.1007/s10517-008-0085-7

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  • DOI: https://doi.org/10.1007/s10517-008-0085-7

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