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Bulletin of Experimental Biology and Medicine

, Volume 145, Issue 3, pp 323–327 | Cite as

Cardioprotective effect of histidine-containing dipeptides in pharmacological cold cardioplegia

  • L. A. Bokeriya
  • A. A. Boldyrev
  • R. R. Movsesyan
  • S. A. Alikhanov
  • E. S. Arzumanyan
  • E. D. Nisnevich
  • T. V. Artyukhina
  • R. A. Serov
Biophysics and Biochemistry

Abstract

The cardioprotective effect of cardioplegic solution based on histidine-containing dipeptides was evaluated on isolated rat heart under conditions of hyporthermia and long ischemia. The use of natural dipeptides in cardioplegic solutions promoted an increase in the buffer capacity of myocardial cells and creation of an additional anti-ischemic effect under conditions of long ischemia and hypothermia.

Key Words

cardiosurgery cardioplegic solution histidine-containing dipeptides carnosine acetylacarnosine 

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Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • L. A. Bokeriya
    • 1
  • A. A. Boldyrev
    • 2
  • R. R. Movsesyan
    • 1
  • S. A. Alikhanov
    • 1
  • E. S. Arzumanyan
    • 2
  • E. D. Nisnevich
    • 1
  • T. V. Artyukhina
    • 1
  • R. A. Serov
    • 1
  1. 1.A. N. Bakulev Institute of Cardiovascular SurgeryRussian Academy of Medical SciencesMoscowRussia
  2. 2.M. V. Lomonosov Moscow State UniversityMoscowRussia

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